Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 0.66 |
| ▸ | HTR2C | P28335 | 9/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
| ▸ | RBP4 | P02753 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4794769 | 0.92 | HTR2A (0.67) | HTR2AHTR2CKCNH2ABL1BCR | |
| SCHEMBL4782121 | 0.92 | HTR2A (0.61) | HTR2AHTR2CKCNH2ABL1BCR | |
| SCHEMBL4731508 | 0.92 | HTR2A (0.65) | HTR2AHTR2CKCNH2ABL1BCR | |
| SCHEMBL4784431 | 0.91 | HTR2A (0.66) | HTR2AHTR2CKCNH2ABL1BCR | |
| SCHEMBL4782575 | 0.90 | HTR2A (0.65) | HTR2AHTR2CKCNH2ABL1BCR | |
| SCHEMBL4783291 | 0.89 | HTR2A (0.61) | HTR2AHTR2CKCNH2ABL1BCR | |
| SCHEMBL4781280 | 0.89 | HTR2A (0.66) | HTR2AHTR2CKCNH2TSHRALDH1A1 | |
| SCHEMBL4784682 | 0.88 | HTR2A (0.62) | HTR2AHTR2CKCNH2ABL1BCR | |
| SCHEMBL4847938 | 0.87 | HTR2A (0.56) | HTR2AHTR2CKCNH2ABL1BCR | |
| SCHEMBL4797482 | 0.86 | HTR2A (0.62) | HTR2AHTR2CKCNH2ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | claimed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |