Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.59 |
| ▸ | PDE2A | O00408 | 1/20 | 0.59 |
| ▸ | PDE1A | P54750 | 1/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726288 | 0.86 | PDE5A (0.58) | PDE5APDE11A | |
| SCHEMBL4726725 | 0.86 | PDE11A (0.51) | PDE5APDE11A | |
| SCHEMBL4726006 | 0.84 | PDE11A (0.69) | PDE5APDE11A | |
| SCHEMBL4728638 | 0.82 | PDE11A (0.64) | PDE5APDE11A | |
| SCHEMBL4781370 | 0.79 | POLB (0.35) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL4727824 | 0.77 | PDE11A (0.65) | PDE11A | |
| SCHEMBL4726841 | 0.76 | PDE11A (0.60) | PDE11A | |
| SCHEMBL492485 | 0.75 | PDE5A (1.00) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL4727805 | 0.75 | PDE11A (0.63) | PDE11A | |
| SCHEMBL10267709 | 0.74 | PDE5A (0.76) | PDE5APDE2APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020711-A1 | QUINAZOLINE DERIVATIVE AS PHOSPHODIESTERASE INHIBITOR AND A PROCESS FOR PREPARING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2008-02-21 | — | — | WO | claimed |
| WO-2008020711-A1 | QUINAZOLINE DERIVATIVE AS PHOSPHODIESTERASE INHIBITOR AND A PROCESS FOR PREPARING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2008-02-21 | — | — | WO | disclosed |