Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 4/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781374 | 0.79 | PDE5A (0.59) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL4726725 | 0.67 | PDE11A (0.51) | PDE5AALDH1A1NPC1HTT | |
| SCHEMBL4726288 | 0.66 | PDE5A (0.58) | PDE5A | |
| SCHEMBL4726006 | 0.64 | PDE11A (0.69) | PDE5A | |
| SCHEMBL4728638 | 0.62 | PDE11A (0.64) | PDE5A | |
| SCHEMBL27377285 | 0.59 | PDE5A (0.48) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL1428266 | 0.58 | GAA (0.49) | POLBALDH1A1RAB9ANPC1GAA | |
| SCHEMBL29213144 | 0.58 | CYP1A2 (0.48) | POLBALDH1A1RAB9ANPC1GAA | |
| SCHEMBL3885787 | 0.58 | ALDH1A1 (0.40) | POLBALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14829845 | 0.57 | KMT2A (0.45) | POLBALDH1A1RAB9ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020711-A1 | QUINAZOLINE DERIVATIVE AS PHOSPHODIESTERASE INHIBITOR AND A PROCESS FOR PREPARING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2008-02-21 | — | — | WO | claimed |
| WO-2008020711-A1 | QUINAZOLINE DERIVATIVE AS PHOSPHODIESTERASE INHIBITOR AND A PROCESS FOR PREPARING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2008-02-21 | — | — | WO | disclosed |