Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667171 | 1.00 | MAPT (0.57) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4669561 | 0.96 | MAPT (0.56) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL5196596 | 0.82 | SMN1; SMN2 (0.43) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL13654228 | 0.82 | KMT2A (0.56) | MAPTALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4667322 | 0.81 | MAPT (0.60) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4666749 | 0.81 | MAPT (0.56) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4668417 | 0.80 | MAPT (0.55) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4668652 | 0.79 | HRH3 (0.58) | HRH3NOTUM | |
| SCHEMBL4032425 | 0.78 | HRH1 (0.48) | MAPTALDH1A1KMT2AMEN1GPR119 | |
| SCHEMBL4668251 | 0.78 | TBK1 (0.42) | MAPTALDH1A1LMNASMN1; SMN2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802307-B1 | PYRROLIDINE DERIVATIVES AS HISTAMINE RECEPTORS LIGANDS | GLAXO GROUP LTD (GB) | 2008-02-27 | — | — | EP | claimed |