Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 3/20 | 0.35 |
| ▸ | FNTB | P49356 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5709066 | 0.94 | NR1H4 (0.56) | NR1H4KMT2AATM | |
| SCHEMBL14677825 | 0.94 | NR1H4 (0.62) | NR1H4KMT2AATM | |
| SCHEMBL6231057 | 0.93 | NR1H4 (0.54) | NR1H4KMT2AATM | |
| SCHEMBL5706924 | 0.93 | NR1H4 (0.56) | NR1H4KMT2AATM | |
| SCHEMBL4617439 | 0.93 | NR1H4 (0.55) | NR1H4KMT2AATM | |
| SCHEMBL5709130 | 0.92 | NR1H4 (0.55) | NR1H4KMT2AATM | |
| SCHEMBL4597959 | 0.91 | NR1H4 (0.54) | NR1H4KMT2AATM | |
| SCHEMBL5706923 | 0.91 | NR1H4 (0.56) | NR1H4KMT2AATM | |
| SCHEMBL5709135 | 0.90 | NR1H4 (0.52) | NR1H4KMT2AATM | |
| SCHEMBL4598052 | 0.89 | NR1H4 (0.51) | NR1H4FNTAFNTBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039829-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-04-03 | — | — | WO | disclosed |
| WO-2006102674-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2006-09-28 | — | — | WO | disclosed |
| EP-1699758-A1 | DIPHENYLAZETIDINONE DERIVATES PROCESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061451-A1 | DIPHENYLAZETIDINONE DERIVATES PROCESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |