Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | CAPNS1 | P04632 | 2/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 8/20 | 0.32 |
| ▸ | CASP1 | P29466 | 7/20 | 0.32 |
| ▸ | CASP7 | P55210 | 7/20 | 0.32 |
| ▸ | CASP6 | P55212 | 7/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 7/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4619436 | 0.96 | NR1H4 (0.50) | NR1H4CAPNS1CAPN1CASP3CASP1 | |
| SCHEMBL14677825 | 0.94 | NR1H4 (0.62) | NR1H4CAPNS1CAPN1KMT2AATM | |
| SCHEMBL5709066 | 0.94 | NR1H4 (0.56) | NR1H4KMT2AATMELANE | |
| SCHEMBL5706924 | 0.94 | NR1H4 (0.56) | NR1H4KMT2AATMELANE | |
| SCHEMBL4782435 | 0.92 | NR1H4 (0.55) | NR1H4KMT2AATM | |
| SCHEMBL5706923 | 0.92 | NR1H4 (0.56) | NR1H4KMT2AATM | |
| SCHEMBL6231057 | 0.92 | NR1H4 (0.54) | NR1H4KMT2AATM | |
| SCHEMBL4597959 | 0.92 | NR1H4 (0.54) | NR1H4KMT2AATM | |
| SCHEMBL5709135 | 0.91 | NR1H4 (0.52) | NR1H4KMT2AATMCASP3CASP1 | |
| SCHEMBL4617439 | 0.91 | NR1H4 (0.55) | NR1H4KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699759-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061452-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |