SCHEMBL4782693

SCHEMBL4782693

COC1=CC=CCN1c1ccc(-c2ccccc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OXTR P30559 1/20 0.35
MCHR1 Q99705 1/20 0.34
EGLN1 Q9GZT9 1/20 0.32
USP2 O75604 3/20 0.32
HSD17B10 Q99714 2/20 0.32
ALDH1A1 P00352 2/20 0.32
CYP3A4 P08684 2/20 0.32
CYP1A2 P05177 1/20 0.32
GLA P06280 1/20 0.32
APP P05067 1/20 0.32
FAAH O00519 1/20 0.32
MGLL Q99685 1/20 0.32
HTR1A P08908 1/20 0.32
CRHBP P24387 1/20 0.32
CRHR2 Q13324 1/20 0.32
TP53 P04637 2/20 0.31
CYP2D6 P10635 2/20 0.31
MAPK1 P28482 2/20 0.31
CYP2C9 P11712 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28060781 0.69 NPC1 (0.36) GLAMAPK1SMN1; SMN2
SCHEMBL3441740 0.63
SCHEMBL16786525 0.62 MEN1 (0.48) USP2HSD17B10ALDH1A1CYP3A4CYP1A2
SCHEMBL7789814 0.61 KMT2A (0.32) ALDH1A1CRHBPCRHR2
SCHEMBL28270415 0.60 ALDH1A1 (0.41) HSD17B10ALDH1A1CYP3A4CYP1A2MAPK1
Biphenyl SCHEMBL27543063 0.60 ALDH1A1 (0.41) HSD17B10ALDH1A1CYP3A4CYP1A2MAPK1
SCHEMBL5229204 0.60 NPC1 (0.38)
Biphenyl SCHEMBL27702269 0.59 ALDH1A1 (0.45) HSD17B10ALDH1A1CYP3A4CYP1A2MAPK1
Biphenyl SCHEMBL28881047 0.59 ALDH1A1 (0.69) HSD17B10ALDH1A1CYP3A4CYP1A2MAPK1
Biphenyl SCHEMBL3908169 0.59 ALDH1A1 (0.69) HSD17B10ALDH1A1CYP3A4CYP1A2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008039829-A2 DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS IRONWOOD PHARMACEUTICALS, INC. (US) 2008-04-03 WO disclosed
EP-0759754-A4 A METHOD OF MODIFYING ANGIOTENSIN RECEPTOR ACTIVITY FOR TREATMENT OF PREMENSTRUAL SYNDROME AND MEDIATION OF PAIN DEPADOVA ANTHONY S (US) 2000-07-05 EP disclosed
EP-0759754-A1 A METHOD OF MODIFYING ANGIOTENSIN RECEPTOR ACTIVITY FOR TREATMENT OF PREMENSTRUAL SYNDROME AND MEDIATION OF PAIN DePadova, Anthony S. (US) 1997-03-05 EP disclosed
WO-1995029674-A1 A METHOD OF MODIFYING ANGIOTENSIN RECEPTOR ACTIVITY FOR TREATMENT OF PREMENSTRUAL SYNDROME AND MEDIATION OF PAIN DEPADOVA ANTHONY S (US) 1995-11-09 WO disclosed