Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 7/20 | 0.60 |
| ▸ | PLK3 | Q9H4B4 | 6/20 | 0.60 |
| ▸ | PLK2 | Q9NYY3 | 4/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | TAF1 | P21675 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | NEK4 | P51957 | 1/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783506 | 0.91 | PLK1 (0.57) | PLK1PLK3PLK2ALKBRD4 | |
| SCHEMBL4886676 | 0.89 | PLK1 (0.56) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL4798215 | 0.87 | PLK1 (0.55) | PLK1PLK3PLK2BRD4PARP1 | |
| SCHEMBL4782583 | 0.87 | PLK1 (0.55) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL4731693 | 0.85 | PLK1 (0.54) | PLK1PLK3PLK2BRD4PARP1 | |
| SCHEMBL4730395 | 0.85 | PLK1 (0.54) | PLK1PLK3PLK2BRD4PARP1 | |
| SCHEMBL4779460 | 0.85 | PLK1 (0.54) | PLK1PLK3PLK2BRD4PARP1 | |
| SCHEMBL4784197 | 0.85 | PLK1 (0.56) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL4780462 | 0.85 | PLK1 (0.53) | PLK1PLK3PLK2BRD4PARP1 | |
| SCHEMBL4784694 | 0.85 | PLK1 (0.59) | PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |