Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 8/20 | 0.56 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 4/20 | 0.45 |
| ▸ | TAF1 | P21675 | 2/20 | 0.45 |
| ▸ | PLK2 | Q9NYY3 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782583 | 0.90 | PLK1 (0.55) | PLK1PLK3ABL1BRD4TAF1 | |
| SCHEMBL4782722 | 0.89 | PLK1 (0.60) | PLK1PLK3BRD4TAF1PLK2 | |
| SCHEMBL4783506 | 0.88 | PLK1 (0.57) | PLK1PLK3BRD4TAF1PLK2 | |
| SCHEMBL4784197 | 0.87 | PLK1 (0.56) | PLK1PLK3BRD4TAF1PLK2 | |
| SCHEMBL4780462 | 0.87 | PLK1 (0.53) | PLK1PLK3BRD4PLK2AURKA | |
| SCHEMBL4798215 | 0.86 | PLK1 (0.55) | PLK1PLK3BRD4PLK2AURKA | |
| SCHEMBL4731562 | 0.85 | PLK1 (0.54) | PLK1PLK3BRD4PLK2PLK4 | |
| SCHEMBL4782678 | 0.85 | PLK1 (0.57) | PLK1PLK3BRD4TAF1PLK2 | |
| SCHEMBL4848371 | 0.84 | PLK1 (0.69) | PLK1PLK3ABL1BRD4TAF1 | |
| SCHEMBL4731693 | 0.84 | PLK1 (0.54) | PLK1PLK3ABL1BRD4PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |