Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908075 | 0.80 | LTA4H (0.57) | MEN1KMT2ATSHROPRM1SIGMAR1 | |
| SCHEMBL27827514 | 0.75 | LTA4H (0.55) | ALDH1A1TSHRMAPK1LMNARAB9A | |
| SCHEMBL11876127 | 0.72 | BCHE (0.53) | MEN1KMT2ATSHRRAB9ANPC1 | |
| SCHEMBL11876060 | 0.72 | ESR2 (0.54) | MEN1KMT2ATSHRLTA4HTDP1 | |
| SCHEMBL8061283 | 0.72 | ESR1 (0.54) | ALDH1A1MEN1KMT2ATSHRHPGD | |
| SCHEMBL3022050 | 0.71 | CYP19A1 (0.37) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL6799479 | 0.68 | CYP19A1 (0.50) | MAPTSNCAPOLBCYP19A1 | |
| SCHEMBL11878258 | 0.68 | CYP2D6 (0.60) | MEN1KMT2ATSHRMAPTKDM4E | |
| SCHEMBL4845293 | 0.68 | TSHR (0.41) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL16515936 | 0.68 | CYP19A1 (0.42) | ALDH1A1MEN1KMT2ATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008036643-A2 | AMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2008-03-27 | — | — | WO | disclosed |