Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.54 |
| ▸ | SCARB1 | Q8WTV0 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727932 | 0.87 | SCARB1 (0.54) | RORCSCARB1NPC1KMT2AMEN1 | |
| SCHEMBL4028758 | 0.83 | SCARB1 (0.72) | RORCSCARB1NPC1CNR2HDAC6 | |
| SCHEMBL4780961 | 0.81 | SCARB1 (0.61) | RORCSCARB1NPC1KMT2AMEN1 | |
| SCHEMBL4726208 | 0.80 | CNR2 (0.67) | RORCNPC1CNR2 | |
| SCHEMBL4028735 | 0.77 | SCARB1 (0.79) | RORCSCARB1NPC1TP53HSD17B10 | |
| SCHEMBL4195549 | 0.74 | SCARB1 (0.68) | RORCSCARB1NPC1HDAC6HSD17B10 | |
| SCHEMBL4030252 | 0.73 | SCARB1 (0.70) | RORCSCARB1NPC1HDAC6HSD17B10 | |
| SCHEMBL25815123 | 0.73 | KMT2A (0.61) | KMT2AMEN1MAPT | |
| SCHEMBL25811779 | 0.73 | KMT2A (0.58) | RORCKMT2AMEN1MAPT | |
| SCHEMBL4560319 | 0.73 | SCARB1 (0.61) | RORCSCARB1NPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021745-A2 | HEPATITIS C VIRUS ENTRY INHIBITORS | ITHERX PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |