Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.46 |
| ▸ | CTSD | P07339 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | CTSE | P14091 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858017 | 0.80 | BACE1 (0.48) | BACE1BACE2CTSDCYP1A2CYP11B1 | |
| SCHEMBL4532523 | 0.80 | BACE1 (0.68) | BACE1BACE2CTSDREN | |
| SCHEMBL13711462 | 0.76 | BACE1 (0.44) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL4519233 | 0.75 | BACE1 (0.42) | BACE1BACE2CTSDKCNH2 | |
| Hydrochloric Acid SCHEMBL5137186 | 0.74 | BACE1 (0.38) | BACE1BACE2CTSDCTSE | |
| SCHEMBL4805777 | 0.72 | BACE1 (0.73) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL4532172 | 0.71 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL4520674 | 0.70 | BACE1 (0.66) | BACE1BACE2CTSDREN | |
| SCHEMBL4525852 | 0.70 | BACE1 (0.71) | BACE1BACE2CTSDREN | |
| SCHEMBL5134308 | 0.69 | BACE1 (0.43) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | claimed |