Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4681335 | 0.84 | CNR1 (0.51) | CNR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL4680862 | 0.79 | CNR1 (0.59) | CNR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL5754413 | 0.78 | CNR1 (0.50) | CNR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL4678461 | 0.76 | CNR1 (0.47) | CNR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL4680181 | 0.74 | CNR1 (0.52) | CNR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL4676300 | 0.73 | SMN1; SMN2 (0.52) | CNR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL4680311 | 0.71 | CNR1 (0.46) | CNR1ALDH1A1SMN1; SMN2L3MBTL1PLA2G1B | |
| SCHEMBL4677242 | 0.70 | CNR1 (0.46) | CNR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL4679820 | 0.70 | TARBP2 (0.55) | KDM4E | |
| SCHEMBL4680964 | 0.68 | CNR1 (0.52) | CNR1KDM4EALDH1A1PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-B1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |