Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680862 | 0.88 | CNR1 (0.59) | CNR1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL4680181 | 0.87 | CNR1 (0.52) | CNR1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL4676300 | 0.79 | SMN1; SMN2 (0.52) | CNR1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL4783347 | 0.78 | CNR1 (0.48) | CNR1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL4680964 | 0.76 | CNR1 (0.52) | CNR1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL4681335 | 0.76 | CNR1 (0.51) | CNR1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL4677242 | 0.76 | CNR1 (0.46) | CNR1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL4679820 | 0.76 | TARBP2 (0.55) | KDM4EMAPTNPC1RAB9ADHODH | |
| SCHEMBL4676636 | 0.75 | CNR1 (0.50) | CNR1ALDH1A1KDM4EDHODHHPGD | |
| SCHEMBL4681021 | 0.75 | CNR1 (0.57) | CNR1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-A1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | AstraZeneca AB (SE) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004111034-A1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2004-12-23 | — | — | WO | disclosed |