Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 8/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 4/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | WNT3 | P56703 | 1/20 | 0.33 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4794680 | 0.86 | NR1H2 (0.46) | PFKFB3NR1H2CNR2PPARGCNR1 | |
| SCHEMBL4784546 | 0.86 | NR1H2 (0.46) | PFKFB3NR1H2CNR2PPARGSLC22A12 | |
| SCHEMBL4785061 | 0.84 | NR1H2 (0.37) | NR1H2CNR2CNR1WNT3SFRP1 | |
| SCHEMBL4784035 | 0.84 | NR1H2 (0.46) | NR1H2SLC22A12WNT3SFRP1 | |
| SCHEMBL4780533 | 0.82 | NR1H2 (0.43) | PFKFB3NR1H2CNR2PPARGCNR1 | |
| SCHEMBL4780535 | 0.81 | NR1H2 (0.44) | PFKFB3NR1H2CNR2PPARGADRA2A | |
| SCHEMBL4784502 | 0.81 | TRPV4 (0.45) | NR1H2CNR2CTSLCTSSCTSK | |
| SCHEMBL4782680 | 0.80 | NR1H2 (0.39) | PFKFB3NR1H2CNR2PPARGCTSL | |
| SCHEMBL2372639 | 0.79 | CNR2 (0.48) | PFKFB3CNR2CTSLCTSSCTSK | |
| SCHEMBL4785515 | 0.79 | NR1H2 (0.41) | PFKFB3NR1H2CNR2PPARGCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |