Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 10/20 | 0.53 |
| ▸ | PLK3 | Q9H4B4 | 10/20 | 0.53 |
| ▸ | PLK2 | Q9NYY3 | 9/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.44 |
| ▸ | CDK9 | P50750 | 4/20 | 0.44 |
| ▸ | STK4 | Q13043 | 2/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854326 | 0.84 | PLK1 (0.67) | PLK1PLK3PLK2STK4 | |
| SCHEMBL4783143 | 0.83 | PLK1 (0.70) | PLK1PLK3PLK2STK4 | |
| SCHEMBL4799693 | 0.82 | PLK1 (0.54) | PLK1PLK3PLK2STK4 | |
| SCHEMBL4729390 | 0.82 | PLK1 (0.56) | PLK1PLK3PLK2STK4 | |
| SCHEMBL4784598 | 0.81 | PLK1 (0.53) | PLK1PLK3PLK2STK4 | |
| SCHEMBL14221001 | 0.80 | PLK1 (0.54) | PLK1PLK3PLK2STK4 | |
| SCHEMBL4784197 | 0.80 | PLK1 (0.56) | PLK1PLK3PLK2 | |
| SCHEMBL4729386 | 0.79 | PLK1 (0.53) | PLK1PLK3PLK2 | |
| SCHEMBL4782801 | 0.79 | PLK1 (0.53) | PLK1PLK3PLK2STK4 | |
| SCHEMBL4782907 | 0.79 | PLK1 (0.53) | PLK1PLK3PLK2STK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |