Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 10/20 | 0.53 |
| ▸ | PLK3 | Q9H4B4 | 10/20 | 0.53 |
| ▸ | PLK2 | Q9NYY3 | 9/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | STK3 | Q13188 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3C2G | O75747 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | STK4 | Q13043 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782235 | 0.91 | PLK1 (0.52) | PLK1PLK3PLK2 | |
| SCHEMBL4784433 | 0.85 | PLK1 (0.52) | PLK1PLK3PLK2AURKAAURKB | |
| SCHEMBL4854326 | 0.82 | PLK1 (0.67) | PLK1PLK3PLK2STK3PIK3CD | |
| SCHEMBL4783376 | 0.81 | PLK1 (0.53) | PLK1PLK3PLK2STK4 | |
| SCHEMBL4783143 | 0.81 | PLK1 (0.70) | PLK1PLK3PLK2STK3STK4 | |
| SCHEMBL4799693 | 0.81 | PLK1 (0.54) | PLK1PLK3PLK2STK4 | |
| SCHEMBL4729390 | 0.80 | PLK1 (0.56) | PLK1PLK3PLK2STK4 | |
| SCHEMBL4782049 | 0.79 | PLK1 (0.55) | PLK1PLK3PLK2AURKB | |
| SCHEMBL14221001 | 0.79 | PLK1 (0.54) | PLK1PLK3PLK2STK4 | |
| SCHEMBL4784197 | 0.78 | PLK1 (0.56) | PLK1PLK3PLK2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |