Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | CDK4 | P11802 | 3/20 | 0.47 |
| ▸ | CCND1 | P24385 | 3/20 | 0.47 |
| ▸ | CCND2 | P30279 | 3/20 | 0.47 |
| ▸ | CCND3 | P30281 | 3/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | PAK4 | O96013 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | LTK | P29376 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.45 |
| ▸ | MST1R | Q04912 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781952 | 0.89 | CDK4 (0.53) | PLK1PLK3CDK4CCND1CCND2 | |
| SCHEMBL4844864 | 0.86 | PLK1 (0.52) | PLK1PLK3CDK4CCND1CCND2 | |
| SCHEMBL14221236 | 0.85 | PLK1 (0.55) | PLK1PLK3CDK4CCND1CCND2 | |
| SCHEMBL4781914 | 0.84 | PLK1 (0.52) | PLK1PLK3CDK4CCND1CCND3 | |
| SCHEMBL4729262 | 0.83 | PLK1 (0.56) | PLK1PLK3PIP4K2APIP4K2BBRD4 | |
| SCHEMBL4781788 | 0.83 | PLK1 (0.60) | PLK1PLK3ALKPTK2MAP4K4 | |
| SCHEMBL14220956 | 0.82 | PLK1 (0.56) | PLK1PLK3SYKCDK4CCND1 | |
| SCHEMBL4730395 | 0.82 | PLK1 (0.54) | PLK1PLK3CSF1RPIP4K2APIP4K2B | |
| SCHEMBL4782049 | 0.82 | PLK1 (0.55) | PLK1PLK3AURKBPIP4K2APIP4K2B | |
| SCHEMBL4779878 | 0.82 | PLK1 (0.54) | PLK1PLK3PIP4K2APIP4K2BBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |