Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.53 |
| ▸ | CCND1 | P24385 | 11/20 | 0.53 |
| ▸ | CCND2 | P30279 | 7/20 | 0.53 |
| ▸ | CCND3 | P30281 | 7/20 | 0.53 |
| ▸ | CDK1 | P06493 | 5/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.53 |
| ▸ | CDK2 | P24941 | 5/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.53 |
| ▸ | PLK1 | P53350 | 4/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.50 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783471 | 0.89 | PLK1 (0.51) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL14220956 | 0.88 | PLK1 (0.56) | CDK4CCND1CCND3CDK1CCNE1 | |
| SCHEMBL4729390 | 0.87 | PLK1 (0.56) | PLK1PLK3PLK2 | |
| SCHEMBL14221236 | 0.86 | PLK1 (0.55) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL4801699 | 0.86 | PLK1 (0.48) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL4800962 | 0.86 | PLK1 (0.52) | CDK4CCND1CCND2CCND3PLK1 | |
| SCHEMBL14221001 | 0.86 | PLK1 (0.54) | PLK1PLK3PLK2 | |
| SCHEMBL4784197 | 0.85 | PLK1 (0.56) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL4782801 | 0.84 | PLK1 (0.53) | PLK1PLK3PLK2 | |
| SCHEMBL4729386 | 0.84 | PLK1 (0.53) | PLK1PLK3DCLK1LRRK2PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |