Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL5618267 | 0.85 | MRGPRX4 (0.46) | EPHX2KDM4EGAAKMT2APPARA | |
| SCHEMBL4737264 | 0.85 | HDAC6 (0.53) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL5132961 | 0.84 | ALOX15 (0.54) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL5132984 | 0.83 | HDAC6 (0.51) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL4737672 | 0.81 | HDAC8 (0.47) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL5129029 | 0.81 | ITK (0.56) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL4796231 | 0.80 | HDAC6 (0.54) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL19360603 | 0.79 | MRGPRX4 (0.49) | EPHX2NR1H4KDM4EGAAKMT2A | |
| SCHEMBL5131169 | 0.77 | HDAC6 (0.51) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL4736580 | 0.76 | SMPD1 (0.44) | HDAC6HDAC1HDAC3HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109178-A9 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS INC (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2007109178-A2 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2007-09-27 | — | — | WO | claimed |
| WO-2007109178-A9 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS INC (US) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008061160-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2007109178-A2 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |