Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.48 |
| ▸ | KDR | P35968 | 18/20 | 0.48 |
| ▸ | MST1R | Q04912 | 5/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2282590 | 0.90 | MET (0.48) | METKDRMST1RBRD4 | |
| SCHEMBL12376910 | 0.82 | MET (0.60) | METKDRMST1R | |
| SCHEMBL2533739 | 0.82 | MET (0.51) | METKDRMST1R | |
| SCHEMBL2539124 | 0.81 | MET (0.48) | METKDRMST1R | |
| SCHEMBL2282864 | 0.80 | MST1R (0.51) | METKDRMST1R | |
| SCHEMBL2282327 | 0.80 | MET (0.41) | METKDRMST1RBRD4 | |
| SCHEMBL2282585 | 0.79 | MET (0.49) | METKDRMST1R | |
| SCHEMBL2285261 | 0.78 | MET (0.58) | METKDRMST1R | |
| SCHEMBL2354715 | 0.78 | MET (0.57) | METKDRMST1R | |
| SCHEMBL2282452 | 0.78 | MET (0.55) | METKDRMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989211-A2 | HETEROBICYCLIC THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | Array Biopharma, Inc. (US) | 2008-11-12 | — | — | EP | disclosed |
| WO-2008063202-A2 | HETEROBICYCLIC THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | ARRAY BIOPHARMA INC. (US) | 2008-05-29 | — | — | WO | disclosed |