Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 3/20 | 0.44 |
| ▸ | MTTP | P55157 | 3/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784168 | 0.91 | NR1H2 (0.40) | APOBMTTPNR1H2SLC2A1NR1H3 | |
| SCHEMBL4785197 | 0.90 | NR1H2 (0.45) | APOBMTTPNR1H2SLC2A1FABP4 | |
| SCHEMBL4783379 | 0.86 | NR1H2 (0.43) | APOBMTTPNR1H2SLC2A1NR1H3 | |
| SCHEMBL4780458 | 0.83 | POLB (0.44) | APOBMTTPNR1H2NR1H3 | |
| SCHEMBL4780456 | 0.83 | POLB (0.44) | APOBMTTPNR1H2NR1H3 | |
| SCHEMBL4783715 | 0.82 | NR1H2 (0.46) | APOBMTTPNR1H2FFAR4FFAR1 | |
| SCHEMBL4783160 | 0.82 | NR1H2 (0.45) | APOBMTTPNR1H2SLC2A1FFAR4 | |
| SCHEMBL4785575 | 0.81 | NR1H2 (0.43) | APOBMTTPNR1H2SLC2A1 | |
| SCHEMBL4784981 | 0.81 | NR1H2 (0.43) | APOBMTTPNR1H2NR1H3FFAR1 | |
| SCHEMBL4782467 | 0.81 | NR1H2 (0.43) | APOBMTTPNR1H2NR1H3FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |