Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.43 |
| ▸ | APOB | P04114 | 4/20 | 0.42 |
| ▸ | MTTP | P55157 | 4/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | SFRP1 | Q8N474 | 4/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 2/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783715 | 0.93 | NR1H2 (0.46) | NR1H2APOBMTTPFFAR4SFRP1 | |
| SCHEMBL4782467 | 0.92 | NR1H2 (0.43) | NR1H2APOBMTTPFFAR4SFRP1 | |
| SCHEMBL4783160 | 0.91 | NR1H2 (0.45) | NR1H2APOBMTTPFFAR4SFRP1 | |
| SCHEMBL4781106 | 0.91 | APOB (0.47) | NR1H2APOBMTTPSFRP1FFAR1 | |
| SCHEMBL4785197 | 0.89 | NR1H2 (0.45) | NR1H2APOBMTTPFFAR4SFRP1 | |
| SCHEMBL4784895 | 0.89 | APOB (0.46) | NR1H2APOBMTTPSFRP1FFAR1 | |
| SCHEMBL4784068 | 0.89 | NR1H2 (0.44) | NR1H2APOBMTTPNR1H3ALOX5AP | |
| SCHEMBL4783332 | 0.89 | NR1H2 (0.43) | NR1H2APOBMTTPSFRP1FFAR1 | |
| SCHEMBL4783983 | 0.86 | APOB (0.44) | NR1H2APOBMTTPFFAR4SFRP1 | |
| SCHEMBL4781127 | 0.86 | NR1H2 (0.51) | NR1H2APOBMTTPFFAR4SFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |