Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 6/20 | 0.43 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783187 | 0.91 | NR1H2 (0.44) | NR1H2SFRP1PPARGMAPT | |
| SCHEMBL4781466 | 0.86 | NR1H2 (0.47) | NR1H2SFRP1HDAC8 | |
| SCHEMBL4782721 | 0.86 | NR1H2 (0.41) | NR1H2SFRP1MAPTPDK2HDAC8 | |
| SCHEMBL4794680 | 0.84 | NR1H2 (0.46) | NR1H2SFRP1PPARGHDAC8MCHR1 | |
| SCHEMBL4785036 | 0.81 | NR1H2 (0.45) | NR1H2PDK2GRIA2CNR1CNR2 | |
| SCHEMBL4780535 | 0.81 | NR1H2 (0.44) | NR1H2SFRP1PPARGHDAC8MCHR1 | |
| SCHEMBL4780533 | 0.80 | NR1H2 (0.43) | NR1H2SFRP1PPARGHDAC8MCHR1 | |
| SCHEMBL4636821 | 0.79 | SFRP1 (0.63) | SFRP1 | |
| SCHEMBL4781542 | 0.79 | PTGDR2 (0.44) | NR1H2SFRP1MAPTMCHR1ADRA2A | |
| SCHEMBL4784546 | 0.79 | NR1H2 (0.46) | NR1H2SFRP1PPARGMAPTMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |