Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 12/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 11/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727293 | 0.88 | RAF1 (0.55) | RAF1MAPK14BRAF | |
| SCHEMBL4780389 | 0.87 | RAF1 (0.53) | KMT2ARAF1MAPTMAPK14BRAF | |
| SCHEMBL4781713 | 0.87 | MAPK14 (0.53) | RAF1MAPK14BRAFTSHR | |
| SCHEMBL4727303 | 0.85 | MAPK14 (0.52) | RAF1MAPTMAPK14BRAF | |
| SCHEMBL4728270 | 0.85 | MAPK14 (0.51) | RAF1MAPK14BRAF | |
| SCHEMBL4783505 | 0.85 | MAPK14 (0.49) | LMNARAF1MAPK14NPC1RAB9A | |
| SCHEMBL4784013 | 0.84 | NPC1 (0.49) | RAF1MAPTMAPK14NPC1RAB9A | |
| SCHEMBL4728328 | 0.83 | RAF1 (0.54) | RAF1MAPK14BRAF | |
| SCHEMBL4781325 | 0.82 | RAF1 (0.55) | RAF1MAPTBRAF | |
| SCHEMBL4727827 | 0.82 | MAPK14 (0.56) | RAF1MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |