Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 17/20 | 0.48 |
| ▸ | BRAF | P15056 | 16/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727305 | 0.85 | RAF1 (0.53) | RAF1BRAFMAPK14 | |
| SCHEMBL4784010 | 0.84 | LMNA (0.47) | NPC1MAPTRAB9ARAF1BRAF | |
| SCHEMBL4781325 | 0.82 | RAF1 (0.55) | MAPTRAF1BRAF | |
| SCHEMBL4727829 | 0.82 | RAF1 (0.51) | RAF1BRAF | |
| SCHEMBL4729395 | 0.80 | RAF1 (0.49) | RAF1BRAF | |
| SCHEMBL4781805 | 0.80 | RAF1 (0.47) | RAF1BRAF | |
| SCHEMBL4727498 | 0.79 | RAF1 (0.53) | RAF1BRAF | |
| SCHEMBL4727385 | 0.79 | RAF1 (0.56) | RAF1BRAFMAPK14 | |
| SCHEMBL4727198 | 0.78 | RAF1 (0.51) | RAF1BRAFMAPK14 | |
| SCHEMBL4727081 | 0.78 | RAF1 (0.49) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |