Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 9/20 | 0.58 |
| ▸ | BRD4 | O60885 | 5/20 | 0.51 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.51 |
| ▸ | TAF1 | P21675 | 2/20 | 0.50 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.46 |
| ▸ | PLK2 | Q9NYY3 | 8/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780669 | 0.99 | PLK1 (0.59) | PLK1PLK3BRD4BRDTTAF1 | |
| SCHEMBL14220956 | 0.93 | PLK1 (0.56) | PLK1PLK3BRD4BRDTTAF1 | |
| SCHEMBL4887339 | 0.88 | PLK1 (0.62) | PLK1PLK3BRD4TAF1MAPK7 | |
| SCHEMBL4729390 | 0.86 | PLK1 (0.56) | PLK1PLK3BRD4TAF1MAPK7 | |
| SCHEMBL14221001 | 0.84 | PLK1 (0.54) | PLK1PLK3BRD4TAF1MAPK7 | |
| SCHEMBL4784197 | 0.84 | PLK1 (0.56) | PLK1PLK3BRD4TAF1MAPK7 | |
| SCHEMBL4834705 | 0.83 | PLK1 (0.54) | PLK1PLK3BRD4TAF1MAPK7 | |
| SCHEMBL4729386 | 0.83 | PLK1 (0.53) | PLK1PLK3BRD4TAF1MAPK7 | |
| SCHEMBL4782801 | 0.83 | PLK1 (0.53) | PLK1PLK3BRD4TAF1MAPK7 | |
| SCHEMBL4779668 | 0.83 | PLK1 (0.53) | PLK1PLK3BRD4TAF1MAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |