Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | SFRP1 | Q8N474 | 5/20 | 0.42 |
| ▸ | WNT3 | P56703 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 10/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.37 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782504 | 0.82 | NR1H2 (0.55) | NR1H2SFRP1WNT3SLC22A12MAPT | |
| SCHEMBL4784211 | 0.81 | NR1H2 (0.48) | NR1H2SFRP1WNT3SLC22A12MAPT | |
| SCHEMBL4784882 | 0.81 | NR1H2 (0.53) | NR1H2SFRP1WNT3SLC22A12MEN1 | |
| SCHEMBL4784216 | 0.81 | NR1H2 (0.49) | NR1H2SFRP1WNT3SLC22A12MAPT | |
| SCHEMBL4784035 | 0.80 | NR1H2 (0.46) | NR1H2SFRP1WNT3SLC22A12MEN1 | |
| SCHEMBL4785610 | 0.79 | NR1H2 (0.54) | NR1H2SFRP1WNT3SLC22A12MEN1 | |
| SCHEMBL4783738 | 0.78 | NR1H2 (0.55) | NR1H2SFRP1WNT3SLC22A12MEN1 | |
| SCHEMBL4733742 | 0.75 | NR1H2 (0.55) | NR1H2SFRP1WNT3MEN1ALDH1A1 | |
| SCHEMBL4784546 | 0.75 | NR1H2 (0.46) | NR1H2SFRP1WNT3SLC22A12MAPT | |
| SCHEMBL4732746 | 0.73 | CA1 (0.56) | NR1H2SFRP1WNT3SLC22A12MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |