Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.85 |
| ▸ | TSHR | P16473 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4194748 | 0.94 | HPGD (0.97) | HPGDTSHRMAPTSMN1; SMN2POLB | |
| SCHEMBL2105339 | 0.81 | HPGD (0.74) | HPGDTSHRMAPTSMN1; SMN2POLB | |
| SCHEMBL979056 | 0.81 | KEAP1 (0.55) | HPGDTSHRMAPTSMN1; SMN2POLB | |
| SCHEMBL32668944 | 0.81 | KEAP1 (0.55) | HPGDTSHRMAPTSMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL9488278 | 0.79 | KEAP1 (0.53) | HPGDTSHRMAPTSMN1; SMN2POLB | |
| SCHEMBL27617055 | 0.76 | KEAP1 (0.50) | HPGDTSHRMAPTSMN1; SMN2POLB | |
| SCHEMBL6554857 | 0.73 | HPGD (0.71) | HPGDTSHRPOLBUSP2HTT | |
| SCHEMBL5110700 | 0.73 | POLB (0.66) | HPGDTSHRPOLBUSP2HTT | |
| Glyoxylate SCHEMBL7813107 | 0.73 | KEAP1 (0.47) | HPGDTSHRMAPTSMN1; SMN2POLB | |
| SCHEMBL12674484 | 0.73 | MEN1 (0.74) | HPGDTSHRMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |