Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788880 | 0.88 | BTK (0.43) | BTKMAPK14 | |
| SCHEMBL4787917 | 0.83 | BTK (0.66) | BTKMAPK14 | |
| SCHEMBL4788983 | 0.82 | BTK (0.44) | BTKMAPK14 | |
| SCHEMBL20558365 | 0.74 | KDM4E (0.53) | BTK | |
| SCHEMBL14069739 | 0.74 | BTK (0.44) | BTKMAPK14 | |
| SCHEMBL14070272 | 0.72 | BTK (0.54) | BTKMAPK14NPC1 | |
| SCHEMBL14070273 | 0.71 | BTK (0.52) | BTKMAPK14 | |
| SCHEMBL14069740 | 0.71 | BTK (0.42) | BTKMAPK14 | |
| SCHEMBL20558511 | 0.71 | BTK (0.66) | BTKPOLBMAPK14NPC1 | |
| SCHEMBL14070268 | 0.70 | BTK (0.51) | BTKMAPK14NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |