Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784859 | 0.88 | BTK (0.45) | BTKMAPK14 | |
| SCHEMBL14069739 | 0.87 | BTK (0.44) | BTKBRD4CA12CA1CA9 | |
| SCHEMBL14069740 | 0.84 | BTK (0.42) | BTKBRD4CA12CA1CA9 | |
| SCHEMBL4787917 | 0.79 | BTK (0.66) | BTKMAPK14AURKAAURKBSYK | |
| SCHEMBL18164367 | 0.75 | BMX (0.49) | BTKMAPK14 | |
| SCHEMBL24951580 | 0.74 | BTK (0.41) | BTKSYK | |
| SCHEMBL30202892 | 0.74 | BTK (0.41) | BTKSYK | |
| SCHEMBL4411685 | 0.74 | MAPT (0.40) | BRD4MAPK14RORC | |
| SCHEMBL4263103 | 0.74 | CYP17A1 (0.44) | — | |
| SCHEMBL29537649 | 0.72 | SYK (0.46) | AURKAAURKBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |