Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 4/20 | 0.65 |
| ▸ | BRAF | P15056 | 10/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.64 |
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | AXL | P30530 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648035 | 0.91 | MAPK13 (0.79) | MAPK13BRAFMAPK14ABL1AXL | |
| SCHEMBL4648911 | 0.90 | MAPK13 (0.69) | MAPK13BRAFMAPK14ABL1AXL | |
| SCHEMBL1410397 | 0.90 | MAPK13 (0.81) | MAPK13BRAFMAPK14ABL1AXL | |
| SCHEMBL4689912 | 0.89 | MAPK13 (0.68) | MAPK13BRAFMAPK14ABL1AXL | |
| SCHEMBL4689397 | 0.89 | MAPK14 (0.69) | MAPK13BRAFMAPK14ABL1AXL | |
| SCHEMBL14538174 | 0.89 | MAPK13 (0.76) | MAPK13BRAFMAPK14ABL1AXL | |
| SCHEMBL4648639 | 0.89 | MAPK14 (0.75) | MAPK13BRAFMAPK14ABL1AXL | |
| SCHEMBL4788187 | 0.88 | MAPK13 (0.67) | MAPK13BRAFMAPK14ABL1AXL | |
| SCHEMBL4694554 | 0.88 | MAPK13 (0.62) | MAPK13BRAFMAPK14ABL1AXL | |
| SCHEMBL4648831 | 0.87 | BRAF (0.53) | MAPK13BRAFMAPK14ABL1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960394-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Bayer HealthCare AG (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007059202-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE AG (DE) | 2007-05-24 | — | — | WO | disclosed |