Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.54 |
| ▸ | HRH2 | P25021 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27738433 | 0.83 | HRH4 (0.62) | HRH4HRH2HRH1HRH3ADORA2A | |
| SCHEMBL4735759 | 0.80 | HRH4 (0.57) | HRH4HRH2HRH1HRH3ADORA2A | |
| SCHEMBL4785362 | 0.78 | HRH4 (0.55) | HRH4HRH2HRH1HRH3ADORA2A | |
| SCHEMBL4738394 | 0.76 | HRH4 (0.54) | HRH4HRH2HRH1HRH3ADORA2A | |
| SCHEMBL6134444 | 0.72 | ADORA2A (0.51) | HRH4HRH2HRH1HRH3ADORA2A | |
| SCHEMBL2165268 | 0.71 | HRH4 (0.59) | HRH4HRH3ADORA2AADORA1POLB | |
| SCHEMBL13125713 | 0.70 | HRH4 (1.00) | HRH4HTR3A | |
| SCHEMBL30463625 | 0.69 | DHFR (0.56) | HRH4HRH3ADORA2AADORA1HTR3A | |
| SCHEMBL2167151 | 0.69 | HRH4 (0.61) | HRH4HRH2HRH1HRH3HTR3A | |
| SCHEMBL1774054 | 0.69 | HRH4 (0.51) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008074445-A1 | NOVEL TRICYCLIC AND HETEROTRICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THEREOF | UCB PHARMA, S.A. (BE) | 2008-06-26 | — | — | WO | disclosed |