Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721653 | 0.81 | KCNN4 (0.34) | KCNN4PTPN1USP2RAB9ACYP3A4 | |
| SCHEMBL19510596 | 0.80 | CA1 (0.43) | PTPN1IDO1GSK3BCA1CA2 | |
| SCHEMBL4701959 | 0.78 | CYP19A1 (0.41) | CYP19A1GSK3B | |
| SCHEMBL6352845 | 0.78 | SIRT2 (0.33) | KCNN4PTPN1USP2RAB9ACYP3A4 | |
| SCHEMBL2281974 | 0.77 | TSHR (0.50) | KCNN4PTPN1CYP2C9CYP2C19CA1 | |
| SCHEMBL1721847 | 0.75 | KCNN4 (0.37) | KCNN4USP2RAB9ACYP3A4CYP2D6 | |
| SCHEMBL3746053 | 0.75 | LOXL2 (0.44) | KCNN4USP2RAB9ACYP3A4CYP2D6 | |
| SCHEMBL17583204 | 0.75 | KCNN4 (0.41) | KCNN4USP2RAB9ACYP3A4CYP2D6 | |
| SCHEMBL11024439 | 0.73 | CYP3A4 (0.50) | KCNN4PTPN1USP2RAB9ACYP3A4 | |
| SCHEMBL25119775 | 0.73 | KCNN4 (0.42) | KCNN4USP2RAB9ACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |