Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6242277 | 0.88 | METAP1 (0.46) | METAP1NPC1ATRSMN1; SMN2CA12 | |
| SCHEMBL4784848 | 0.84 | METAP1 (0.44) | METAP1NPC1SMN1; SMN2CA12CA1 | |
| SCHEMBL5240239 | 0.82 | MAPT (0.41) | NPC1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL4608245 | 0.80 | CYP1A2 (0.48) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL9291119 | 0.79 | METAP1 (0.50) | METAP1NPC1ATRSMN1; SMN2MEN1 | |
| SCHEMBL5728169 | 0.78 | KMT2A (0.41) | METAP1ATRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL14510093 | 0.77 | METAP1 (0.49) | METAP1NPC1SMN1; SMN2CA12CA1 | |
| SCHEMBL2106155 | 0.77 | NPC1 (0.66) | NPC1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL437283 | 0.76 | METAP1 (0.48) | METAP1NPC1ATRSMN1; SMN2MEN1 | |
| SCHEMBL395773 | 0.76 | METAP1 (0.48) | METAP1NPC1ATRSMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597247-B1 | SUBSTITUTED 3-(BENZOYLUREIDO)-THIOPHENE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-07-23 | — | — | EP | disclosed |