Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | EGFR | P00533 | 3/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14207350 | 0.81 | TDP1 (0.71) | KDREGFRPDGFRBMAPTTHRB | |
| SCHEMBL4785935 | 0.77 | KDM4E (0.51) | KDREGFRPDGFRBMAPTKDM4E | |
| SCHEMBL14207894 | 0.73 | KDR (0.57) | KDREGFRPDGFRBMAPT | |
| SCHEMBL5467454 | 0.70 | MAPT (0.54) | KDREGFRPDGFRBMAPTKDM4E | |
| SCHEMBL18540842 | 0.70 | MAPT (0.66) | KDREGFRPDGFRBMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL5462520 | 0.69 | MAPT (0.53) | KDREGFRPDGFRBMAPTKDM4E | |
| SCHEMBL3108501 | 0.68 | NPY5R (0.72) | KDREGFRPDGFRBMAPTKDM4E | |
| SCHEMBL19033036 | 0.68 | NR4A1 (0.51) | KDREGFRPDGFRBMAPTKDM4E | |
| SCHEMBL13578943 | 0.68 | NR4A1 (0.51) | KDREGFRPDGFRBMAPTKDM4E | |
| SCHEMBL4802046 | 0.68 | THRB (0.64) | KDREGFRPDGFRBMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057402-A2 | N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-05-15 | — | — | WO | disclosed |
| WO-2008057402-A2 | N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-05-15 | — | — | WO | disclosed |