Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.81 |
| ▸ | RPS6KB1 | P23443 | 12/20 | 0.81 |
| ▸ | PDPK1 | O15530 | 11/20 | 0.81 |
| ▸ | PRKACA | P17612 | 2/20 | 0.59 |
| ▸ | PRKACG | P22612 | 2/20 | 0.59 |
| ▸ | PRKACB | P22694 | 2/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | AKT2 | P31751 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.55 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896615 | 0.90 | AKT1 (1.00) | AKT1RPS6KB1PDPK1PRKACAPRKACG | |
| SCHEMBL4786820 | 0.90 | AKT1 (1.00) | AKT1RPS6KB1PDPK1PRKACAPRKACG | |
| SCHEMBL4741691 | 0.82 | PDPK1 (0.81) | AKT1RPS6KB1PDPK1PIM1AKT2 | |
| SCHEMBL4745072 | 0.80 | AKT1 (0.80) | AKT1RPS6KB1PDPK1PRKACAPRKACG | |
| SCHEMBL4745246 | 0.76 | PDPK1 (1.00) | AKT1RPS6KB1PDPK1 | |
| SCHEMBL4742341 | 0.76 | PDPK1 (1.00) | AKT1RPS6KB1PDPK1 | |
| SCHEMBL4743582 | 0.76 | PDPK1 (1.00) | AKT1RPS6KB1PDPK1 | |
| SCHEMBL4744386 | 0.74 | PDPK1 (0.81) | AKT1RPS6KB1PDPK1 | |
| SCHEMBL4786701 | 0.74 | PDPK1 (0.72) | AKT1RPS6KB1PDPK1 | |
| SCHEMBL4787420 | 0.73 | PDPK1 (0.86) | AKT1RPS6KB1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008109613-A1 | BENZO[C][2,7]NAPHTHYRIDINE DERIVATIVES, AND THEIR USE AS KINASE INHIBITORS | WYETH (US) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | AKT1 157/4885RPS6KB1 250/4885PDPK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.