SCHEMBL4786006

SCHEMBL4786006

Cc1nc(C(=O)N2CCCC[C@H]2CN)c(-c2cccc(Cl)c2)s1

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 20/20 0.67
HCRTR2 O43614 20/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4787101 0.97 HCRTR1 (0.70) HCRTR1HCRTR2
SCHEMBL1398853 0.93 HCRTR1 (0.62) HCRTR1HCRTR2
SCHEMBL4786362 0.90 HCRTR1 (0.68) HCRTR1HCRTR2
SCHEMBL3047103 0.88 HCRTR1 (0.53) HCRTR1HCRTR2
SCHEMBL4741190 0.87 HCRTR1 (0.71) HCRTR1HCRTR2
SCHEMBL4783539 0.87 HCRTR1 (0.71) HCRTR1HCRTR2
Hydrochloric Acid SCHEMBL3043151 0.87 HCRTR1 (0.52) HCRTR1HCRTR2
Hydrochloric Acid SCHEMBL3043159 0.87 HCRTR1 (0.52) HCRTR1HCRTR2
SCHEMBL4787721 0.85 HCRTR1 (0.56) HCRTR1HCRTR2
SCHEMBL4739196 0.85 HCRTR1 (0.65) HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008087611-A2 PYRROLIDINE- AND PIPERIDINE- BIS-AMIDE DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2008-07-24 WO disclosed