Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.59 |
| ▸ | MAPT | P10636 | 10/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.55 |
| ▸ | MEN1 | O00255 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | POLB | P06746 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | CDC25A | P30304 | 1/20 | 0.53 |
| ▸ | CDC25B | P30305 | 1/20 | 0.53 |
| ▸ | CDC25C | P30307 | 1/20 | 0.53 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785620 | 0.91 | KMT2A (0.59) | SMN1; SMN2MAPTKDM4ELMNAKMT2A | |
| SCHEMBL4749961 | 0.88 | MEN1 (0.56) | SMN1; SMN2MAPTKDM4ELMNAKMT2A | |
| SCHEMBL4787032 | 0.88 | SMN1; SMN2 (0.66) | SMN1; SMN2MAPTKDM4ELMNAKMT2A | |
| SCHEMBL4788085 | 0.88 | MAPT (0.61) | SMN1; SMN2MAPTKDM4ELMNAKMT2A | |
| SCHEMBL4785626 | 0.86 | SMN1; SMN2 (0.78) | SMN1; SMN2MAPTKDM4ELMNAKMT2A | |
| SCHEMBL4786962 | 0.81 | KMT2A (0.58) | SMN1; SMN2MAPTKDM4ELMNAKMT2A | |
| SCHEMBL4786953 | 0.81 | KMT2A (0.58) | SMN1; SMN2MAPTKDM4ELMNAKMT2A | |
| SCHEMBL4786960 | 0.81 | KMT2A (0.58) | SMN1; SMN2MAPTKDM4ELMNAKMT2A | |
| SCHEMBL4788500 | 0.81 | MAPT (0.69) | SMN1; SMN2MAPTKDM4ELMNAKMT2A | |
| SCHEMBL4788498 | 0.81 | MAPT (0.69) | SMN1; SMN2MAPTKDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |