SCHEMBL4786470

SCHEMBL4786470

COc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1NC(=O)c1ccncc1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.63
FASN P49327 19/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4786113 0.89 FASN (0.54) LMNAFASN
SCHEMBL4732219 0.88 FASN (0.73) FASN
SCHEMBL4736114 0.86 FASN (0.58) FASN
SCHEMBL4736925 0.86 FASN (0.58) FASN
SCHEMBL4781007 0.86 FASN (0.54) FASN
SCHEMBL4735392 0.86 FASN (0.65) FASN
SCHEMBL4785691 0.86 FASN (0.56) LMNAFASN
SCHEMBL4736246 0.85 FASN (0.59) LMNAFASN
SCHEMBL4194951 0.84 FASN (0.61) FASN
SCHEMBL4736935 0.84 FASN (0.56) FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008059214-A1 BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS ASTRAZENECA AB (SE) 2008-05-22 WO claimed
WO-2008059214-A1 BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS ASTRAZENECA AB (SE) 2008-05-22 WO disclosed