SCHEMBL4735392

SCHEMBL4735392

COc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1NC(=O)c1ccc(NC(C)=O)nc1

nearest known ligand 0.65

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FASN P49327 20/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4734406 0.91 FASN (0.61) FASN
SCHEMBL4736245 0.90 FASN (0.79) FASN
SCHEMBL4786470 0.86 LMNA (0.63) FASN
SCHEMBL4784111 0.82 FASN (0.72) FASN
SCHEMBL4732404 0.82 FASN (0.63) FASN
SCHEMBL4734847 0.82 FASN (0.80) FASN
SCHEMBL4781007 0.81 FASN (0.54) FASN
SCHEMBL4735998 0.81 FASN (0.72) FASN
SCHEMBL4736246 0.81 FASN (0.59) FASN
SCHEMBL4732891 0.80 FASN (0.95) FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008059214-A1 BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS ASTRAZENECA AB (SE) 2008-05-22 WO disclosed