Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680099 | 0.96 | TP53 (0.39) | TP53THRBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4682460 | 0.92 | ALDH1A1 (0.41) | ALDH1A1HPGDSMN1; SMN2ALPLCYP2C19 | |
| SCHEMBL4683379 | 0.92 | TP53 (0.42) | TP53THRBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4679811 | 0.91 | CYP2C19 (0.41) | ALDH1A1HPGDSMN1; SMN2ALPLCYP2C19 | |
| SCHEMBL4680655 | 0.88 | TP53 (0.42) | TP53THRBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4682942 | 0.84 | CYP2C19 (0.46) | ALDH1A1HPGDSMN1; SMN2CYP2C19MAOA | |
| SCHEMBL4684180 | 0.78 | CYP2C19 (0.39) | TP53THRBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4683095 | 0.77 | CYP2C19 (0.46) | ALDH1A1HPGDSMN1; SMN2CYP2C19MAOA | |
| SCHEMBL13673710 | 0.73 | CYP2C19 (0.55) | ALDH1A1HPGDSMN1; SMN2ALPLCYP2C19 | |
| SCHEMBL4739381 | 0.73 | CYP2C19 (0.46) | ALDH1A1HPGDSMN1; SMN2CYP2C19MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943247-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007023245-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | disclosed |