Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.78 |
| ▸ | LMNA | P02545 | 5/20 | 0.78 |
| ▸ | MEN1 | O00255 | 5/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.78 |
| ▸ | HPGD | P15428 | 3/20 | 0.78 |
| ▸ | HTT | P42858 | 2/20 | 0.78 |
| ▸ | RECQL | P46063 | 1/20 | 0.78 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.66 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.65 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | CDC25A | P30304 | 1/20 | 0.64 |
| ▸ | CDC25B | P30305 | 1/20 | 0.64 |
| ▸ | CDC25C | P30307 | 1/20 | 0.64 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.64 |
| ▸ | PARP1 | P09874 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786629 | 1.00 | MAPT (0.78) | MAPTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL4788500 | 0.94 | MAPT (0.69) | MAPTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL4788498 | 0.94 | MAPT (0.69) | MAPTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL4788491 | 0.94 | MAPT (0.69) | MAPTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL4788085 | 0.88 | MAPT (0.61) | MAPTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL3611745 | 0.88 | SMN1; SMN2 (0.82) | MAPTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL3611749 | 0.88 | SMN1; SMN2 (0.82) | MAPTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL4788877 | 0.87 | MAPT (0.59) | MAPTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL4749881 | 0.86 | SMN1; SMN2 (0.59) | MAPTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL4787807 | 0.86 | MAPT (0.61) | MAPTSMN1; SMN2KDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |