Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | CCKBR | P32239 | 2/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | KIF11 | P52732 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28478851 | 1.00 | CYP2D6 (1.00) | CYP2D6TSHRMAPK1KDM4EMEN1 | |
| SCHEMBL29630317 | 1.00 | CYP2D6 (1.00) | CYP2D6TSHRMAPK1KDM4EMEN1 | |
| SCHEMBL3481444 | 1.00 | CYP2D6 (1.00) | CYP2D6TSHRMAPK1KDM4EMEN1 | |
| SCHEMBL764194 | 1.00 | CYP2D6 (1.00) | CYP2D6TSHRMAPK1KDM4EMEN1 | |
| SCHEMBL17760630 | 1.00 | CYP2D6 (1.00) | CYP2D6TSHRMAPK1KDM4EMEN1 | |
| SCHEMBL2215687 | 0.92 | CYP2D6 (0.85) | CYP2D6TSHRMAPK1KDM4EMEN1 | |
| SCHEMBL17760541 | 0.91 | CYP2D6 (0.83) | CYP2D6TSHRMAPK1KDM4EMEN1 | |
| SCHEMBL32689432 | 0.91 | CYP2D6 (0.83) | CYP2D6TSHRMAPK1KDM4EMEN1 | |
| SCHEMBL32689431 | 0.91 | CYP2D6 (0.83) | CYP2D6TSHRMAPK1KDM4EMEN1 | |
| SCHEMBL17760584 | 0.91 | CYP2D6 (0.83) | CYP2D6TSHRMAPK1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208033-B2 | β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives and preparation methods same and use in aspects of preventing and treating plant viruses, fungicides and insecticides | NANKAI UNIVERSITY (CN) | 2019-02-19 | — | — | US | disclosed |
| EP-3091015-B1 | BETA-CARBOLINE, DIHYDRO-BETA-CARBOLINE AND TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES AND METHOD FOR PREPARING SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | UNIV NANKAI (CN) | 2019-02-13 | — | — | EP | disclosed |
| US-20160326166-A1 | ß-CARBOLINE, DIHYDRO-ß-CARBOLINE AND TETRAHYDRO-ß-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | NANKAI UNIVERSITY (CN) | 2016-11-10 | — | — | US | disclosed |
| US-20160326166-A1 | ß-CARBOLINE, DIHYDRO-ß-CARBOLINE AND TETRAHYDRO-ß-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | NANKAI UNIVERSITY (CN) | 2016-11-10 | — | — | US | disclosed |
| US-20160326166-A1 | ß-CARBOLINE, DIHYDRO-ß-CARBOLINE AND TETRAHYDRO-ß-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | NANKAI UNIVERSITY (CN) | 2016-11-10 | — | — | US | disclosed |
| WO-2016069949-A1 | COMPOSITIONS AND FORMULATIONS OF METHYLERTHRITOL PHOSPHATE PATHWAY INHIBITORS AND USES THEREOF | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2016-05-06 | — | — | WO | disclosed |
| WO-2015101206-A1 | Β-CARBOLINE, DIHYDRO-Β-CARBOLINE AND TETRAHYDRO-Β-CARBOLINE ALKALOID DERIVATIVES AND METHOD FOR PREPARING SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | 南开大学 | 2015-07-09 | — | — | WO | disclosed |
| WO-2008101824-A1 | IMIDAZO[1',5':1,6] PYRIDO[3,4-B]INDOLES DERIVATIVES AND THERAPEUTICAL USE THEREOF | FOURTILLAN (FR) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326166-A1 | ß-CARBOLINE, DIHYDRO-ß-CARBOLINE AND TETRAHYDRO-ß-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | DDT, NOTUM, DDAH1 | CYP2D6 581/4885TSHR 3772/4885MAPK1 3086/4885 |
| US-10208033-B2 | β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives and preparation methods same and use in aspects of preventing and treating plant viruses, fungicides and insecticides | DDT, ZC3HAV1, NOTUM | CYP2D6 681/4885TSHR 3653/4885MAPK1 3051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.