SCHEMBL4787207

SCHEMBL4787207

CN1CCN(c2cccc3c2C[C@H](NC(=O)c2cccc(-c4ccccc4)c2)CC3)CC1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.55
MTNR1B P49286 1/20 0.55
USP30 Q70CQ3 2/20 0.49
DRD4 P21917 5/20 0.48
DRD2 P14416 4/20 0.48
POLB P06746 1/20 0.47
MAPK1 P28482 1/20 0.47
SCN9A Q15858 4/20 0.44
KCNH2 Q12809 3/20 0.44
SCN5A Q14524 2/20 0.44
F11 P03951 1/20 0.44
KLKB1 P03952 1/20 0.44
CTSS P25774 1/20 0.43
ATR Q13535 1/20 0.43
LMNA P02545 1/20 0.43
ALDH1A1 P00352 1/20 0.41
GAA P10253 1/20 0.41
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7031008 0.92 MTNR1A (0.57) MTNR1AMTNR1BDRD4DRD2POLB
SCHEMBL7031005 0.92 MTNR1A (0.57) MTNR1AMTNR1BDRD4DRD2POLB
SCHEMBL7027930 0.92 MTNR1A (0.65) MTNR1AMTNR1BDRD4DRD2POLB
SCHEMBL7027929 0.92 MTNR1A (0.65) MTNR1AMTNR1BDRD4DRD2POLB
SCHEMBL7022199 0.88 MTNR1A (0.60) MTNR1AMTNR1BDRD4DRD2POLB
SCHEMBL7026340 0.88 MTNR1A (0.52) MTNR1AMTNR1BDRD4DRD2SCN9A
SCHEMBL7026344 0.88 MTNR1A (0.52) MTNR1AMTNR1BDRD4DRD2SCN9A
SCHEMBL7022204 0.88 MTNR1A (0.60) MTNR1AMTNR1BDRD4DRD2POLB
SCHEMBL7023930 0.87 NPC1 (0.56) MTNR1AMTNR1BUSP30DRD4DRD2
SCHEMBL7023936 0.87 NPC1 (0.56) MTNR1AMTNR1BUSP30DRD4DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008130323-A1 NOVEL 8-PIPERAZINE-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN ASTRAZENECA AB (SE) 2008-10-30 WO claimed
WO-2008130323-A1 NOVEL 8-PIPERAZINE-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN ASTRAZENECA AB (SE) 2008-10-30 WO disclosed