Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | FER | P16591 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MST1R | Q04912 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 11/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4279723 | 0.94 | IGF1R (0.40) | IGF1RNTRK1NTRK3NTRK2ALK | |
| SCHEMBL1372986 | 0.92 | ALK (0.43) | IGF1RNTRK1NTRK3NTRK2ALK | |
| Hydrochloric Acid SCHEMBL1372982 | 0.92 | ALK (0.42) | IGF1RNTRK1NTRK3NTRK2ALK | |
| Hydrochloric Acid SCHEMBL4278059 | 0.92 | ALK (0.42) | IGF1RNTRK1NTRK3NTRK2ALK | |
| SCHEMBL4291575 | 0.90 | IGF1R (0.49) | IGF1RNTRK1NTRK3NTRK2ALK | |
| SCHEMBL1371541 | 0.90 | IGF1R (0.38) | IGF1RNTRK1NTRK3NTRK2ALK | |
| SCHEMBL1370571 | 0.87 | IGF1R (0.41) | IGF1RNTRK1NTRK3NTRK2ALK | |
| SCHEMBL1371041 | 0.85 | NTRK1 (0.37) | IGF1RNTRK1NTRK3NTRK2ALK | |
| SCHEMBL1372416 | 0.83 | ALDH1A1 (0.36) | NTRK1NTRK3NTRK2 | |
| SCHEMBL1372652 | 0.82 | USP2 (0.34) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963326-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007068637-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-06-21 | — | — | WO | disclosed |