Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 3/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | F12 | P00748 | 3/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1857142 | 0.89 | UCHL1 (0.53) | NR1H2ESR2MAPK1UCHL1SCN9A | |
| SCHEMBL30647075 | 0.89 | UCHL1 (0.53) | NR1H2ESR2MAPK1UCHL1SCN9A | |
| SCHEMBL19374775 | 0.88 | DDB1 (0.52) | NR1H2ESR2MAPK1UCHL1PARP1 | |
| SCHEMBL12312048 | 0.88 | NR1H2 (0.50) | NR1H2ESR2MAPK1UCHL1SCN9A | |
| SCHEMBL21807308 | 0.86 | UCHL1 (0.54) | NR1H2ESR2MAPK1UCHL1SCN9A | |
| SCHEMBL394214 | 0.85 | NR1H2 (0.60) | NR1H2ESR2MAPK1UCHL1SCN9A | |
| SCHEMBL29526229 | 0.85 | NR1H2 (0.60) | NR1H2ESR2MAPK1UCHL1SCN9A | |
| SCHEMBL2122847 | 0.83 | MAPK1 (0.50) | NR1H2ESR2MAPK1UCHL1SCN9A | |
| SCHEMBL1958196 | 0.83 | ESR2 (0.59) | NR1H2ESR2MAPK1UCHL1SCN9A | |
| SCHEMBL11997414 | 0.83 | ESR2 (0.55) | NR1H2ESR2MAPK1UCHL1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001128-A1 | 1,2-CYCL0HEXANE DICARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001128-A1 | 1,2-CYCL0HEXANE DICARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |