Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | TLR3 | O15455 | 1/20 | 0.37 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10102200 | 0.89 | HSP90AA1 (0.46) | HSP90AA1S1PR1HTTSMN1; SMN2NPC1 | |
| SCHEMBL15255527 | 0.89 | S1PR1 (0.43) | S1PR1HTTSMN1; SMN2NPC1MAPT | |
| SCHEMBL15255529 | 0.89 | S1PR1 (0.43) | S1PR1HTTSMN1; SMN2NPC1MAPT | |
| SCHEMBL4788079 | 0.89 | S1PR1 (0.43) | S1PR1HTTSMN1; SMN2NPC1MAPT | |
| SCHEMBL4750955 | 0.81 | HTT (0.43) | HTTSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL4751335 | 0.81 | HTT (0.43) | HTTSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL14042048 | 0.81 | HTT (0.46) | HTTSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL660122 | 0.81 | HTT (0.43) | HTTSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL10107220 | 0.78 | MAPT (0.43) | S1PR1HTTSMN1; SMN2NPC1MAPT | |
| SCHEMBL10102217 | 0.78 | S1PR1 (0.44) | HSP90AA1S1PR1HTTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8536157-B2 | Non-steroidal compounds | THE UNIVERSITY OF MELBOURNE (AU) | 2013-09-17 | — | — | US | disclosed |
| WO-2008124878-A1 | NON-STEROIDAL COMPOUNDS | CRYPTOPHARMA PTY LTD (AU) | 2008-10-23 | — | — | WO | disclosed |