Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 2/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.46 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 8/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | OXGR1 | Q96P68 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4928568 | 0.92 | SUCNR1 (0.39) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4927071 | 0.79 | SUCNR1 (0.44) | ITGB3SUCNR1PTPN1ITGA2BOXGR1 | |
| SCHEMBL4787966 | 0.78 | ITGB1 (0.49) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4248950 | 0.78 | ITGAV (0.69) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4207160 | 0.77 | SUCNR1 (0.43) | ITGB3ITGB1ITGA5SUCNR1PTPN1 | |
| SCHEMBL31085307 | 0.77 | HDAC4 (0.43) | ITGAVITGB6SUCNR1OXGR1CTSK | |
| SCHEMBL21853216 | 0.77 | HDAC4 (0.43) | ITGAVITGB6SUCNR1OXGR1CTSK | |
| SCHEMBL21853215 | 0.77 | HDAC4 (0.43) | ITGAVITGB6SUCNR1OXGR1CTSK | |
| SCHEMBL4205174 | 0.77 | SUCNR1 (0.42) | ITGB1ITGA5SUCNR1OXGR1CTSS | |
| SCHEMBL6424982 | 0.75 | SUCNR1 (0.48) | SUCNR1OXGR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008125811-A1 | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-10-23 | — | — | WO | disclosed |
| US-20080255183-A1 | N-[HETEROARYLCARBONYL]-3-THIENYL-L-ALANINE DERIVATIVES AS a5beta1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-10-16 | — | — | US | disclosed |
| US-20080045521-A1 | PHENYLALANINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255183-A1 | N-[HETEROARYLCARBONYL]-3-THIENYL-L-ALANINE DERIVATIVES AS a5beta1 ANTAGONISTS | ITGA2B, ITGB1, ITGB5 | ITGAV 9/4885ITGB3 5/4885ITGB1 2/4885 |
| US-20080045521-A1 | PHENYLALANINE DERIVATIVES | ITGB5, ITGB1, ITGA2B | ITGAV 17/4885ITGB3 6/4885ITGB1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.