Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.76 |
| ▸ | PRKAA1 | Q13131 | 12/20 | 0.76 |
| ▸ | PRKAA2 | P54646 | 11/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.76 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.76 |
| ▸ | EGFR | P00533 | 4/20 | 0.76 |
| ▸ | CSF1R | P07333 | 3/20 | 0.76 |
| ▸ | FLT3 | P36888 | 3/20 | 0.76 |
| ▸ | PLK4 | O00444 | 2/20 | 0.76 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.76 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.76 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.76 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.76 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.76 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.76 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.76 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.76 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.76 |
| ▸ | INSR | P06213 | 2/20 | 0.76 |
| ▸ | LCK | P06239 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4810472 | 0.89 | KDR (0.80) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL4810470 | 0.89 | KDR (0.80) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL4789091 | 0.89 | KDR (0.75) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL4789092 | 0.89 | KDR (0.75) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL25343935 | 0.86 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL20805212 | 0.86 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL8082 | 0.86 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL25343938 | 0.86 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL30314241 | 0.86 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| Sunitinib SCHEMBL8081 | 0.86 | KDR (1.00) | KDRPRKAA1PRKAA2PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008145398-A1 | 4-ARYLPYRROLE SUBSTITUTED 2-INDOLINE DERIVATIVES ACTIVE AS PROTEIN KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2008-12-04 | — | — | WO | disclosed |